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Inactivation of the receptors and their downregulation and decreased dopamine release is called tolerance, which makes the dependency on smokers and addiction [73]

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Health effects associated with smokeless tobacco: a systematic review

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[DOI] [PMC free article] [PubMed] [Google Scholar] (23).Parkin DM, Muir CS, Whelan S, Gao Y, Ferlay J, and Powell J (1992) Cancer Incidence in Five Continents, Vol